Pathways for nicotinic receptor desensitization
نویسندگان
چکیده
منابع مشابه
Desensitization of Mouse Nicotinic Acetylcholine Receptor Channels
The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery were estimated from the durations and frequencies of clusters of single-channel currents. Diliganded-open AChR desensitize much faster than either unliganded- or diliganded-closed AChR, which indicates that the desensitization rate constant depends on the status of the activation gate rather than the occup...
متن کاملRegulation of Nicotinic Acetylcholine Receptor Desensitization by Ca
Guo X, Lester RA. Regulation of nicotinic acetylcholine receptor desensitization by Ca . J Neurophysiol 97: 93–101, 2007. First published October 18, 2006; doi:10.1152/jn.01047.2005. The relationship between the concentration of intracellular Ca ([Ca ]i) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using th...
متن کاملRegulation of nicotinic acetylcholine receptor desensitization by Ca2+.
The relationship between the concentration of intracellular Ca2+ ([Ca2+](i)) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using the whole cell patch-clamp techniques in combination with microfluorescent [Ca2+](i) measurements. Recovery from desensitization was assessed with a paired-pulse agonist applicatio...
متن کاملDependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure.
When subjected to prolonged exposure to nicotinic agonists, nicotinic acetylcholine receptors undergo desensitization, resulting in an inactive receptor that does not allow for the passage of ions. The induction of desensitization of diverse nicotinic acetylcholine receptor subtypes in muscle, ganglia, or brain is likely to play important modulatory roles in synaptic transmission. Furthermore, ...
متن کاملDesensitization Contributes to the Synaptic Response of Gain-of-Function Mutants of the Muscle Nicotinic Receptor
Although the muscle nicotinic receptor (AChR) desensitizes almost completely in the steady presence of high concentrations of acetylcholine (ACh), it is well established that AChRs do not accumulate in desensitized states under normal physiological conditions of neurotransmitter release and clearance. Quantitative considerations in the framework of plausible kinetic schemes, however, lead us to...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2020
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.202012639